2010

Krug, U., Rollig, C., Koschmieder, A., Heinecke, A., Sauerland, M.C., Schaich, M., Thiede, C., Kramer, M., Braess, J., Spiekermann, K., Haferlach, T., Haferlach, C., Koschmieder, S., Rohde, C., Serve, H., Wormann, B., Hiddemann, W., Ehninger, G., Berdel, W.E., Buchner, T. & Muller-Tidow, C. (2010) Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes. Lancet, 376, 2000-2008.

Falini, B., Martelli, M.P., Tiacci, E., Ascani, S., Thiede, C. & Pileri, S.A. (2010) Immunohistochemical surrogates for genetic alterations of CCDN1, PML, ALK, and NPM1 genes in lymphomas and acute myeloid leukemia. Best Pract Res Clin Haematol, 23, 417-431.

Oelschlaegel, U., Koch, S., Mohr, B., Schaich, M., Falini, B., Ehninger, G. & Thiede, C. (2010) Rapid flow cytometric detection of aberrant cytoplasmic localization of nucleophosmin (NPMc) indicating mutant NPM1 gene in acute myeloid leukemia. Leukemia, 24, 1813-1816.

Martelli, M.P., Pettirossi, V., Thiede, C., Bonifacio, E., Mezzasoma, F., Cecchini, D., Pacini, R., Tabarrini, A., Ciurnelli, R., Gionfriddo, I., Manes, N., Rossi, R., Giunchi, L., Oelschlagel, U., Brunetti, L., Gemei, M., Delia, M., Specchia, G., Liso, A., Di Ianni, M., Di Raimondo, F., Falzetti, F., Del Vecchio, L., Martelli, M.F. & Falini, B. (2010) CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice. Blood, 116, 3907-3922.

Bornhauser, M., Aringer, M. & Thiede, C. (2010) Mixed lymphohematopoietic chimerism and response in Wegener's granulomatosis. N Engl J Med, 362, 2431-2432.

Wermke, M., Maiwald, S., Schmelz, R., Thiede, C., Schetelig, J., Ehninger, G., Bornhauser, M. & Wassmuth, R. (2010) Genetic variations of interleukin-23R (1143A>G) and BPI (A645G), but not of NOD2, are associated with acute graft-versus-host disease after allogeneic transplantation. Biol Blood Marrow Transplant, 16, 1718-1727.

Muller-Tidow, C., Klein, H.U., Hascher, A., Isken, F., Tickenbrock, L., Thoennissen, N., Agrawal-Singh, S., Tschanter, P., Disselhoff, C., Wang, Y., Becker, A., Thiede, C., Ehninger, G., zur Stadt, U., Koschmieder, S., Seidl, M., Muller, F.U., Schmitz, W., Schlenke, P., McClelland, M., Berdel, W.E., Dugas, M. & Serve, H. (2010) Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia. Blood, 116, 3564-3571.

Alchalby, H., Badbaran, A., Zabelina, T., Kobbe, G., Hahn, J., Wolff, D., Bornhauser, M., Thiede, C., Baurmann, H., Bethge, W., Hildebrandt, Y., Bacher, U., Fehse, B., Zander, A.R. & Kroger, N. (2010) Impact of JAK2V617F mutation status, allele burden, and clearance after allogeneic stem cell transplantation for myelofibrosis. Blood, 116, 3572-3581.

Rollig, C., Thiede, C., Gramatzki, M., Aulitzky, W., Bodenstein, H., Bornhauser, M., Platzbecker, U., Stuhlmann, R., Schuler, U., Soucek, S., Kramer, M., Mohr, B., Oelschlaegel, U., Stolzel, F., von Bonin, M., Wermke, M., Wandt, H., Ehninger, G. & Schaich, M. (2010) A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial. Blood, 116, 971-978.

Kohlmann, A., Bullinger, L., Thiede, C., Schaich, M., Schnittger, S., Dohner, K., Dugas, M., Klein, H.U., Dohner, H., Ehninger, G. & Haferlach, T. (2010) Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways. Leukemia, 24, 1216-1220.

Agrawal-Singh, S., Koschmieder, S., Gelsing, S., Stocking, C., Stehling, M., Thiede, C., Thoennissen, N.H., Kohler, G., Valk, P.J., Delwel, R., Mills, K., Baumer, N., Tickenbrock, L., Hansen, K., Berdel, W.E., Muller-Tidow, C. & Serve, H. (2010) Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model. Blood, 115, 4507-4516.

Suttorp, M., Thiede, C., Tauer, J.T., Range, U., Schlegelberger, B. & von Neuhoff, N. (2010) Impact of the type of the BCR-ABL fusion transcript on the molecular response in pediatric patients with chronic myeloid leukemia. Haematologica, 95, 852-853.

Gebhard, C., Benner, C., Ehrich, M., Schwarzfischer, L., Schilling, E., Klug, M., Dietmaier, W., Thiede, C., Holler, E., Andreesen, R. & Rehli, M. (2010) General transcription factor binding at CpG islands in normal cells correlates with resistance to de novo DNA methylation in cancer cells. Cancer Res, 70, 1398-1407.

Stolzel, F., Steudel, C., Oelschlagel, U., Mohr, B., Koch, S., Ehninger, G. & Thiede, C. (2010) Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells. Ann Hematol, 89, 653-662.

Wandt, H., Haferlach, T., Thiede, C. & Ehninger, G. (2010) WHO classification of myeloid neoplasms and leukemia. Blood, 115, 748-749; author reply 749-750.

Khandanpour, C., Thiede, C., Valk, P.J., Sharif-Askari, E., Nuckel, H., Lohmann, D., Horsthemke, B., Siffert, W., Neubauer, A., Grzeschik, K.H., Bloomfield, C.D., Marcucci, G., Maharry, K., Slovak, M.L., van der Reijden, B.A., Jansen, J.H., Schackert, H.K., Afshar, K., Schnittger, S., Peeters, J.K., Kroschinsky, F., Ehninger, G., Lowenberg, B., Duhrsen, U. & Moroy, T. (2010) A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia. Blood, 115, 2462-2472.

Jacobi, A., Thieme, S., Lehmann, R., Ugarte, F., Malech, H.L., Koch, S., Thiede, C., Muller, K., Bornhauser, M., Ryser, M. & Brenner, S. (2010) Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. Exp Hematol, 38, 180-190.

Lauter, A., Strumpf, A., Platzbecker, U., Schetelig, J., Wermke, M., Radke, J., Kiani, A., Wunderlich, G., Thiede, C., Ehninger, G., Kotzerke, J. & Bornhauser, M. (2010) 188Re anti-CD66 radioimmunotherapy combined with reduced-intensity conditioning and in-vivo T cell depletion in elderly patients undergoing allogeneic haematopoietic cell transplantation. Br J Haematol, 148, 910-917.

Stolzel, F., Wermke, M., Rollig, C., Thiede, C., Platzbecker, U. & Bornhauser, M. (2010) Mobilization of PML/RARalpha negative peripheral blood stem cells with a combination of G-CSF and CXCR4 blockade in relapsed acute promyelocytic leukemia pre-treated with arsenic trioxide. Haematologica, 95, 171-172.

Wermke, M., Thiede, C., Kiani, A., Ehninger, G., Bornhauser, M. & Platzbecker, U. (2010) Successful treatment of molecular relapse in NPM1-positive AML using 5-azacytidine. Leukemia, 24, 236-237.